Patsalos, PN;
(2016)
Pediatric antiepileptic drug therapeutic drug monitoring.
Journal of Pediatric Pharmacy
, 2016
(3)
pp. 12-17.
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Abstract
Antiepileptic drugs( AEDs) are the mainstay of epilepsy treatment and there are now 27 licensed AEDs in total for the treatment of patients with epilepsy. This has led to an increasingly widespread application of therapeutic drug monitoring( TDM)making AEDs among the most common medications for which TDM is performed. For the older first generation AEDs( carbamazepine,ethosuximide, phenobarbital, phenytoin, primidone and valproic acid) much data has accumulated in this regard. However, increasingly this is occurring for the new AEDs (eslicarbazepine acetate, felbamate,gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, piracetam, pregabalin, retigabine, rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide). The aim of the present paper is to provide an overview of the indications for AEDs TDM in children. Practical issues such as choice of sample type, sample collection and processing and the concept of the reference range are discussed.
| Type: | Article |
|---|---|
| Title: | Pediatric antiepileptic drug therapeutic drug monitoring |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://caod.oriprobe.com/articles/47585369/Pediatr... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | antiepileptic drugs; therapeutic drug monitoring; pharmacokinetics; drug-drug interactions; saliva |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1505805 |
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