Maçon, ALB;
Jacquemin, M;
Page, SJ;
Li, S;
Bertazzo, S;
Stevens, MM;
Hanna, JV;
(2017)
Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships.
Journal of Sol-Gel Science and Technology
, 81
(1)
pp. 84-94.
10.1007/s10971-016-4097-x.
Preview |
Text
Bertazzo VoR Maçon2017_Article_Lithium-silicateSolGelBioactiv.pdf Download (1MB) | Preview |
Abstract
This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li22O by the sol–gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol–gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 2929Si and 77Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.
| Type: | Article |
|---|---|
| Title: | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10971-016-4097-x |
| Publisher version: | http://dx.doi.org/10.1007/s10971-016-4097-x |
| Language: | English |
| Additional information: | Copyright © 2016 The Author(s). Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Bioactive glass; Lithium; Sol–gel |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1503795 |
Archive Staff Only
 |
View Item |
