McKenner, M; (2016) The Developmental, Diagnostic and Dimensional Interview - Short Form Adult Version (3Di-sva): a tool for assessing autism spectrum disorders in adults – validation in a clinical population. Doctoral thesis , UCL (University College London).

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Abstract

This thesis focuses on the assessment of autism spectrum disorder (ASD) in individuals who have reached adulthood without ever having received a diagnosis and, in particular, on distinguishing features of ASD from those of other mental health difficulties in a potentially complex adult clinical population. / Part 1: This section systematically reviews literature estimating levels of cooccurrence of ASD and psychotic disorders. Fourteen studies investigating the prevalence of psychosis in adults diagnosed with ASD and six studies estimating the prevalence of ASD in adults diagnosed with a psychotic disorder were included. The review concludes that lifetime prevalence of psychosis in adults with ASD may be higher than in the general population and explores factors which might explain an association between these disorders. / Part 2: This section is an empirical paper reporting a study designed to validate the Developmental, Diagnostic and Dimensional Interview - Short Form Adult Version (3Di-sva) in a clinical population. The 3Di-sva is a new informant-report interview for the diagnosis of ASD in adults. The interview was conducted in respect of 27 individuals diagnosed with ASD and 20 clinical comparison participants diagnosed with a range of mental health difficulties. The 3Di-sva was found to display good psychometric properties including interrater reliability, internal consistency, criterion validity and sensitivity and specificity. This research was conducted in collaboration with another UCL Clinical Psychology Doctorate student (Clarke, 2015) who evaluated the psychometric properties of the 3Di-sva when used in a non-clinical comparison population. / Part 3: This section provides a critical appraisal of the systematic literature review and major research project, reflecting on aspects of clinical experience which contributed to the work undertaken, ways in which the process of carrying out the study influenced my perspective on research and clinical practice, and methodological challenges that were encountered.

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