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Impairment on a self-ordered working memory task in patients with early-acquired hippocampal atrophy

Geva, S; Cooper, JM; Gadian, DG; Mishkin, M; Vargha-Khadem, F; (2016) Impairment on a self-ordered working memory task in patients with early-acquired hippocampal atrophy. Developmental Cognitive Neuroscience , 20 pp. 12-22. 10.1016/j.dcn.2016.06.001. Green open access

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Abstract

One of the features of both adult-onset and developmental forms of amnesia resulting from bilateral medial temporal lobe damage, or even from relatively selective damage to the hippocampus, is the sparing of working memory. Recently, however, a number of studies have reported deficits on working memory tasks in patients with damage to the hippocampus and in macaque monkeys with neonatal hippocampal lesions. These studies suggest that successful performance on working memory tasks with high memory load require the contribution of the hippocampus. Here we compared performance on a working memory task (the Self-ordered Pointing Task), between patients with early onset hippocampal damage and a group of healthy controls. Consistent with the findings in the monkeys with neonatal lesions, we found that the patients were impaired on the task, but only on blocks of trials with intermediate memory load. Importantly, only intermediate to high memory load blocks yielded significant correlations between task performance and hippocampal volume. Additionally, we found no evidence of proactive interference in either group, and no evidence of an effect of time since injury on performance. We discuss the role of the hippocampus and its interactions with the prefrontal cortex in serving working memory.

Type: Article
Title: Impairment on a self-ordered working memory task in patients with early-acquired hippocampal atrophy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dcn.2016.06.001
Publisher version: http://dx.doi.org/10.1016/j.dcn.2016.06.001
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Working memory, Hippocampus, MEDIAL TEMPORAL-LOBE, SHORT-TERM-MEMORY, PREFRONTAL CORTEX, FRONTAL-LOBE, RELATIONAL INFORMATION, PARAHIPPOCAMPAL CORTEX, DEVELOPMENTAL AMNESIA, COGNITIVE-PROCESSES, RECOGNITION MEMORY, MACAQUE MONKEYS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: https://discovery.ucl.ac.uk/id/eprint/1501193
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