Perreault, K;
Bauman, A;
Johnson, N;
Britton, A;
Rangul, V;
Stamatakis, E;
(2017)
Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality risk? A pooled analysis of eight British population cohorts.
British Journal of Sports Medcine
, 51
pp. 651-657.
10.1136/bjsports-2016-096194.
Preview |
Text
Perreault et al Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality risk.pdf Download (433kB) | Preview |
Abstract
OBJECTIVE: To examine whether physical activity (PA) moderates the association between alcohol intake and all-cause mortality, cancer mortality and cardiovascular diseases (CVDs) mortality. DESIGN: Prospective study using 8 British population-based surveys, each linked to cause-specific mortality: Health Survey for England (1994, 1998, 1999, 2003, 2004 and 2006) and Scottish Health Survey (1998 and 2003). PARTICIPANTS: 36 370 men and women aged 40 years and over were included with a corresponding 5735 deaths and a mean of 353 049 person-years of follow-up. EXPOSURES: 6 sex-specific categories of alcohol intake (UK units/week) were defined: (1) never drunk; (2) ex-drinkers; (3) occasional drinkers; (4) within guidelines (<14 (women); <21 (men)); (5) hazardous (14–35 (women); 21–49 (men)) and (6) harmful (>35 (women) >49 (men)). PA was categorised as inactive (≤7 MET-hour/week), active at the lower (>7.5 MET-hour/week) and upper (>15 MET-hour/week) of recommended levels. MAIN OUTCOMES AND MEASURES: Cox proportional-hazard models were used to examine associations between alcohol consumption and all-cause, cancer and CVD mortality risk after adjusting for several confounders. Stratified analyses were performed to evaluate mortality risks within each PA stratum. RESULTS: We found a direct association between alcohol consumption and cancer mortality risk starting from drinking within guidelines (HR (95% CI) hazardous drinking: 1.40 (1.11 to 1.78)). Stratified analyses showed that the association between alcohol intake and mortality risk was attenuated (all-cause) or nearly nullified (cancer) among individuals who met the PA recommendations (HR (95% CI)). CONCLUSIONS: Meeting the current PA public health recommendations offsets some of the cancer and all-cause mortality risk associated with alcohol drinking.
| Type: | Article |
|---|---|
| Title: | Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality risk? A pooled analysis of eight British population cohorts |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bjsports-2016-096194 |
| Publisher version: | http://dx.doi.org/10.1136/bjsports-2016-096194 |
| Language: | English |
| Additional information: | Copyright © Article author (or their employer) 2016. Produced by BMJ Publishing Group Ltd under licence. This article has been accepted for publication in the British Journal of Sports Medicine following peer review. The definitive copyedited, typeset version [CITATION INFORMATION] is available online at: http://dx.doi.org/10.1136/bjsports-2016-096194 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1501027 |
Archive Staff Only
 |
View Item |
