Vavourakis, V;
Wijeratne, P;
Shipley, R;
Stylianopoulos, T;
Hawkes, DJ;
(2016)
The Mechanical Underpinning of Tumour-induced Angiogenesis and Growth.
In:
Proceedings of the 24th UK Conference of the Association for Computational Mechanics in Engineering.
Association for Computational Mechanics in Engineering (ACME): Cardiff, UK.
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Abstract
Angiongenic vessel growth is widely acknowledged to be a fundamental process that underpins cancer growth, invasion and metastasis, and it is highly instructive to construct and test reliable mechano-biological models of this process. Whereas previous studies have explored the chemical underpinning of both tumour growth and angiogenesis, here we extend these frameworks significantly to focus on the interplay between angiogenic network evolution and growth-induced solid stresses through a hapto- and mechanotactic stimulus for vessel sprouting, and a mechanics based remodelling process of the microvasculature. The proposed three-dimensional, multiscale in silico model for tumour-induced angiogenesis and growth is validated against in vivo data from murine mammary carcinomas, specifically focusing on the role of mechanical signals in recapitulating experimental evidence.
| Type: | Proceedings paper |
|---|---|
| Title: | The Mechanical Underpinning of Tumour-induced Angiogenesis and Growth |
| Event: | 24th UK Conference of the Association for Computational Mechanics in Engineering |
| Location: | Cardiff, UK |
| Dates: | 30 June 2016 - 01 June 2016 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://acme2016.sciencesconf.org/87678 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cancer mechanics; neo-vascularisation; tumour microenvironment; multiscale model; finite element method |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1500898 |
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