Radzvilavicius, AL;
(2016)
Evolutionary dynamics of cytoplasmic segregation and fusion: Mitochondrial mixing facilitated the evolution of sex at the origin of eukaryotes.
Journal of Theoretical Biology
, 404
pp. 160-168.
10.1016/j.jtbi.2016.05.037.
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Abstract
Sexual reproduction is a trait shared by all complex life, but the complete account of its origin is missing. Virtually all theoretical work on the evolution of sex has been centered around the benefits of reciprocal recombination among nuclear genes, paying little attention to the evolutionary dynamics of multi-copy mitochondrial genomes. Here I develop a mathematical model to study the evolution of nuclear alleles inducing cell fusion in an ancestral population of clonal proto-eukaryotes. Segregational drift maintains high mitochondrial variance between clonally reproducing hosts, but the effect of segregation is opposed by cytoplasmic mixing which tends to reduce variation between cells in favor of higher heterogeneity within the cell. Despite the reduced long-term population fitness, alleles responsible for sexual cell fusion can spread to fixation. The evolution of sex requires negative epistatic interactions between mitochondrial mutations under strong purifying selection, low mutation load and weak mitochondrial-nuclear associations. I argue that similar conditions could have been maintained during the late stages of eukaryogenesis, facilitating the evolution of sexual cell fusion and meiotic recombination without compromising the stability of the emerging complex cell.
| Type: | Article |
|---|---|
| Title: | Evolutionary dynamics of cytoplasmic segregation and fusion: Mitochondrial mixing facilitated the evolution of sex at the origin of eukaryotes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jtbi.2016.05.037 |
| Publisher version: | http://dx.doi.org/10.1016/j.jtbi.2016.05.037 |
| Language: | English |
| Additional information: | Copyright © 2016 The Author. Published by Elsevier Ltd. Open Access funded by Engineering and Physical Sciences Research Council. Made available under a Creative Commons Attribution 4.0 International licence (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Cell fusion, Eukaryogenesis, Negative epistasis, Purifying selection |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1497284 |
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