Francis, L;
Meng, D;
Locke, IC;
Knowles, JC;
Mordan, N;
Salih, V;
Boccaccini, AR;
(2016)
Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications.
Polymer International
, 65
(6)
pp. 661-674.
10.1002/pi.5108.
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Francis et al 2016 Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications.pdf Download (2MB) | Preview |
Abstract
Bioactive glass is considered an ideal material for haemostasis as it releases Ca2+ ions upon hydration, which is required to support thrombosis. In this study the effects of the presence of nanoscaled bioactive glass (n-BG) in poly(3-hydroxybutyrate) (P(3HB)) microsphere films on the structural properties, thermal properties and biocompatibility of the films were studied. The n-BG with a high surface area was also tested for its in vitro haemostatic efficacy and was found to be able to successfully reduce clot detection time. In an effort to study the effect of the roughness induced by the formation of hydroxyapatite on cellular functions such as cell adhesion, cell mobility and cell differentiation, the composite films were immersed in simulated body fluid for periods of 1, 3 and 7 days. From scanning electron microscopy images, the surface of the P(3HB)/n-BG composite microsphere films appeared fairly uniform and smooth on day 1; however on day 3 and day 7 a rough and uneven surface was observed. The presence of hydroxyapatite on the composite microsphere films on day 3 and day 7 influenced the surface roughness of the films. However, when the P(3HB)/n-BG composite microsphere films with enhanced surface roughness were tested for biocompatibility, reduced amounts of protein adsorption and cell adhesion were observed. This study thus revealed that there is an optimal surface roughness for the P(3HB) microsphere films for increased cell adhesion, beyond which it could be deleterious for cell adhesion and differentiation.
| Type: | Article |
|---|---|
| Title: | Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/pi.5108 |
| Publisher version: | http://dx.doi.org/10.1002/pi.5108 |
| Language: | English |
| Additional information: | Copyright © 2016 Society of Chemical Industry. This is the peer reviewed version of the following article: [Francis, L., Meng, D., Locke, I. C., Knowles, J. C., Mordan, N., Salih, V., Boccaccini, A. R. and Roy, I. (2016), Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications. Polym. Int., 65: 661–674. doi: 10.1002/pi.5108], which has been published in final form at http://dx.doi.org/10.1002/pi.5108. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | n-BG; P(3HB) microspheres; n-BG/P(3HB) composite films; bioactive glass; surface roughness; cell response; wound healing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1496671 |
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