Taylor, K;
Iqbal, N;
Vitorino, C;
(2017)
How lipid nanocarriers improve transdermal delivery of olanzapine.
Pharmaceutical Development and Technology
, 22
(4)
pp. 587-596.
10.1080/10837450.2016.1200615.
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Abstract
The development of a transdermal nanocarrier drug delivery system with potential for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, is described. Lipid nanocarriers (LN), encompassing various solid:liquid lipid compositions were formulated and assessed as potential nanosystems for transdermal delivery of olanzapine. A previously optimized method of hot high pressure homogenization (HPH) was adopted for the production of the LN, which comprised solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE). Precirol ® was selected as the solid lipid for progression of studies. SLN exhibited the best performance for transdermal delivery of olanzapine, based on in vitro release and permeation studies, coupled with results from physicochemical characterization of several solid:liquid lipid formulations. Stability tests, performed to give an indication of long-term storage behavior of the formulations, were in good agreement with previous studies for the best choice of solid:liquid lipid ratio. Overall, these findings highlight the SLN-based formulation as promising for the further inclusion in and production of transdermal patches, representing an innovative therapeutic approach.
| Type: | Article |
|---|---|
| Title: | How lipid nanocarriers improve transdermal delivery of olanzapine |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/10837450.2016.1200615 |
| Publisher version: | http://dx.doi.org/10.1080/10837450.2016.1200615 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Lipid nanocarriers; Nanostructured lipid carriers; Solid lipid nanoparticles; Nanoemulsions; Olanzapine; Transdermal drug delivery system |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1493445 |
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