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Effect of scatter correction when comparing attenuation maps: Application to brain PET/MR

Burgos, N; Thielemans, K; Cardoso, MJ; Markiewicz, P; Jiao, J; Dickson, J; Duncan, JS; ... Ourselin, S; + view all (2014) Effect of scatter correction when comparing attenuation maps: Application to brain PET/MR. In: Proceedings of the 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE: Seattle, WA, USA. Green open access

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Abstract

Email Print Request Permissions In PET imaging, attenuation and scatter corrections are an essential requirement to accurately quantify the radionuclide uptake. In the context of PET/MR scanners, obtaining the attenuation information can be challenging. Various authors have quantified the effect of an imprecise attenuation map on the reconstructed PET image but its influence on scatter correction has usually been ignored. In this paper, we investigate the effects of imperfect attenuation maps (μmaps) on the scatter correction in a simulation setting. We focused our study on three μmaps: the reference μmap derived from a CT image, and two MR-based methods. Two scatter estimation strategies were implemented: a μmap-specific scatter estimation and an ideal scatter estimation relying only on the reference CT μmap. The scatter estimation used the Single Scatter Simulation algorithm with tail-fitting. The results show that, for FDG brain PET, regardless of the μmap used in the reconstruction, the difference on PET images between μmap-specific and ideal scatter estimations is small (less than 1%). More importantly, the relative error between attenuation correction methods does not change depending on the scatter estimation method included in the simulation and reconstruction process. This means that the effect of errors in the μmap on the PET image is dominated by the attenuation correction, while the scatter estimate is relatively unaffected. Therefore, while scatter correction improves reconstruction accuracy, it is unnecessary to include scatter in the simulation when comparing different attenuation correction methods for brain PET/MR.

Type: Proceedings paper
Title: Effect of scatter correction when comparing attenuation maps: Application to brain PET/MR
Event: 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
ISBN-13: 9781479960972
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSSMIC.2014.7430775
Publisher version: http://dx.doi.org/10.1109/NSSMIC.2014.7430775
Language: English
Additional information: Copyright © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Keywords: Attenuation, Computed tomography, Estimation, Image reconstruction, Image segmentation, Magnetic resonance imaging, Positron emission tomography
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1493135
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