Mitra, S;
Bale, G;
Meek, J;
Mathieson, S;
Uria, C;
Kendall, G;
Robertson, NJ;
(2016)
In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke.
In: Elwell, CE and Leung, TS and Harrison, DK, (eds.)
Oxygen Transport to Tissue XXXVII.
(pp. 493-499).
Springer New York: New York, NY, USA.
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Abstract
Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2-HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.
Type: | Book chapter |
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Title: | In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke |
ISBN-13: | 9781493930227 |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1007/978-1-4939-3023-4_62 |
Publisher version: | http://dx.doi.org/10.1007/978-1-4939-3023-4_62 |
Language: | English |
Additional information: | Copyright © The Author(s) 2016. This book is distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/3.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
Keywords: | Broadband NIRS, Cerebral hemodynamics, Cytochrome c oxidase, Mitochondrial metabolism, Neonatal stroke |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
URI: | https://discovery.ucl.ac.uk/id/eprint/1491288 |
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