Khalili, H;
Khaw, PT;
Brocchini, S;
(2016)
Fc-fusion mimetics.
Biomaterials Science
, 4
(6)
pp. 943-947.
10.1039/c6bm00077k.
Preview |
Text
Khaw_Uploaded file resubmission RpR paper s1-ln232162911222999360-1939656818Hwf-1990418618IdV37232518523216291PDF_HI0001_extracted.pdf Download (6MB) | Preview |
Abstract
The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
| Type: | Article |
|---|---|
| Title: | Fc-fusion mimetics |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6bm00077k |
| Publisher version: | http://dx.doi.org/10.1039/c6bm00077k |
| Language: | English |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1489997 |
Archive Staff Only
 |
View Item |
