Fullerton, JN;
Gilroy, DW;
(2016)
Resolution of inflammation: a new therapeutic frontier.
Nature Reviews Drug Discovery
, 15
(8)
pp. 551-567.
10.1038/nrd.2016.39.
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Abstract
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.
| Type: | Article |
|---|---|
| Title: | Resolution of inflammation: a new therapeutic frontier |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nrd.2016.39 |
| Publisher version: | http://www.nature.com/nrd/journal/v15/n8/full/nrd.... |
| Language: | English |
| Additional information: | Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Pharmacology & Pharmacy, NF-KAPPA-B, Chronic Granulomatous-disease, Necrosis-factor-alpha, Experimental Autoimmune-thyroiditis, Neutrophil Extracellular Traps, Melanocyte-stimulating Hormone, Persistent Lcmv Infection, Apoptotic Cell Clearance, Messenger-RNA Decay, Acute Lung Injury |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1488818 |
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