Nayagam, JS;
Pereira, SP;
Devlin, J;
Harrison, PM;
Joshi, D;
(2016)
Controversies in the management of primary sclerosing cholangitis.
World Journal of Hepatology
, 8
(5)
pp. 265-272.
10.4254/wjh.v8.i5.265.
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Abstract
Primary sclerosing cholangitis (PSC) remains a rare but significant disease, which affects mainly young males in association with inflammatory bowel disease. There have been few advances in the understanding of the pathogenesis of the condition and no therapeutics with proven mortality benefit aside from liver transplantation. There remain areas of controversy in the management of PSC which include the differentiation from other cholangiopathies, in particular immunoglobulin G4 related sclerosing cholangitis, the management of dominant biliary strictures, and the role of ursodeoxycholic acid. In addition, the timing of liver transplantation in PSC remains difficult to predict with standard liver severity scores. In this review, we address these controversies and highlight the latest evidence base in the management of PSC.
| Type: | Article |
|---|---|
| Title: | Controversies in the management of primary sclerosing cholangitis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4254/wjh.v8.i5.265 |
| Publisher version: | http://dx.doi.org/10.4254/wjh.v8.i5.265 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (http://creativecommons.org/ licenses/by-nc/4.0/), which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. The published journal article is available on the publisher's website at http://dx.doi.org/10.4254/wjh.v8.i5.265 |
| Keywords: | Cholangiocarcinoma, Dominant strictures, Immunoglobulin G4 related sclerosing cholangitis, Liver transplantation, Primary sclerosing cholangitis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1485908 |
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