Titapiwatanakun, V;
Basit, AW;
Gaisford, S;
(2016)
A New Method for Producing Pharmaceutical Co-crystals: Laser Irradiation of Powder Blends.
Crystal Growth & Design
, 16
(6)
pp. 3307-3312.
10.1021/acs.cgd.6b00289.
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Abstract
In this work, a high-power CO2 laser was used to irradiate powder blends of co-crystal formers, with the specific aim of trying to cause recrystallization to a co-crystal structure. By varying the power and raster speed of the laser, it was found that sufficient thermal energy could be imparted to the powder to cause molecular rearrangement. It was possible to form co-crystals of caffeine with oxalic acid and caffeine with malonic acid. Interestingly, it was found that, to form co-crystals successfully, the coformers needed to sublime to an appreciable extent, which indicates that the mechanism of rearrangement involves interaction and nucleation in the vapor phase. Laser irradiation thus offers a new route to creation of pharmaceutical co-crystals and a potentially rapid screen for likely co-crystal formation between coforming pairs.
| Type: | Article |
|---|---|
| Title: | A New Method for Producing Pharmaceutical Co-crystals: Laser Irradiation of Powder Blends |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.cgd.6b00289 |
| Publisher version: | http://dx.doi.org/10.1021/acs.cgd.6b00289 |
| Language: | English |
| Additional information: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see: http://dx.doi.org/10.1021/acs.cgd.6b00289. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1485863 |
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