Tachtsidis, I;
Scholkmann, F;
(2016)
False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward.
Neurophotonics
, 3
(3)
031405.
10.1117/1.NPh.3.3.031405.
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Abstract
We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not due to neurovascular coupling. These can be misinterpreted as brain activity, i.e., "false positives" (errors caused by wrongly assigning a detected hemodynamic response to functional brain activity), or mask brain activity, i.e., "false negatives" (errors caused by wrongly assigning a not observed hemodynamic response in the presence of functional brain activity). Here, we summarize the possible physiological origins of these issues and suggest ways to avoid and remove them.
| Type: | Article |
|---|---|
| Title: | False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.NPh.3.3.031405 |
| Publisher version: | http://dx.doi.org/10.1117/1.NPh.3.3.031405 |
| Language: | English |
| Additional information: | Copyright © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
| Keywords: | functional near-infrared spectroscopy, hemodynamic response |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1484925 |
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