Bai, J;
Wang, JT;
Rubio, N;
Protti, A;
Heidari, H;
Elgogary, R;
Southern, P;
... Al-Jamal, KT; + view all
(2016)
Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.
Theranostics
, 6
(3)
pp. 342-356.
10.7150/thno.11918.
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Abstract
Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
| Type: | Article |
|---|---|
| Title: | Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo |
| Location: | Australia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7150/thno.11918 |
| Publisher version: | http://dx.doi.org/10.7150/thno.11918 |
| Language: | English |
| Additional information: | Copyright © 2015 Ivyspring International Publisher. This article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/) Reproduction is permitted for personal, noncommercial use only, provided that the article is in whole, unmodified, and properly cited. |
| Keywords: | PEGylated PLGA, magnetic resonance imaging, magnetic targeting, nuclear imaging, optical imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1479390 |
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