Stricker, S;
Pollard, S;
(2014)
Reprogramming cancer cells to pluripotency.
Epigenetics
, 9
(6)
pp. 798-802.
10.4161/epi.28600.
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Abstract
The epigenetic marks displayed by a cancer cell originate from two separate processes: The most prominent epigenetic signatures are associated with the cell of origin, i.e., the lineage and cell type identity imposed during development. The second set comprises those aberrant cancer-specific epigenetic marks that appear during tumor initiation or subsequent malignant progression. These are generally thought to associate with tumor-promoting pathways. As biochemical pathways regulating epigenetic mechanisms are potentially “druggable” and reversible, there is considerable interest in defining their roles in tumor genesis and growth, as they may represent therapeutic targets for treatment of human neoplasias. However, despite the potential importance of epigenetic modifications in human cancer, it has been difficult to determine when, where and how epigenetic disruptions occur, and if they have important functional roles in sustaining the malignant state.
| Type: | Article |
|---|---|
| Title: | Reprogramming cancer cells to pluripotency |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4161/epi.28600 |
| Publisher version: | http://dx.doi.org/10.4161/epi.28600 |
| Language: | English |
| Additional information: | Copyright © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License (https://creativecommons.org/licenses/by-nc/3.0/). The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Permission is granted subject to the terms of the License under which the work was published. Please check the License conditions for the work which you wish to reuse. Full and appropriate attribution must be given. This permission does not cover any third party copyrighted material which may appear in the work requested. |
| Keywords: | cancer, DNA methylation, epigenetics, glioblastoma, neural stem cell, polycomb, reprogramming, iPS cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1478352 |
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