Réant, P;
Hauer, AD;
Castelletti, S;
Pantazis, A;
Rosmini, S;
Cheang, MH;
Peyrou, J;
... McKenna, WJ; + view all
(2016)
Epicardial myocardial strain abnormalities may identify the earliest stages of arrhythmogenic cardiomyopathy.
The International Journal of Cardiovascular Imaging
, 32
(4)
pp. 593-601.
10.1007/s10554-015-0813-9.
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Abstract
The aim of this cohort study was to evaluate the value of echocardiographic multilayer strain analysis in the identification of arrhythmogenic cardiomyopathy (AC) in its earliest stages in which sudden cardiac death can occurs. Twenty seven asymptomatic relatives of AC probands (mean age 39.6 ± 19.5 years, 37 % male) with a desmosomal pathogenic mutation but no additional criteria for AC (group II) were compared to age and sex-matched healthy controls (group I). In addition, 70 patients harboring a pathogenic desmosomal mutation with "definitive" diagnosis of AC (group IV), and 19 subjects with "borderline" diagnosis (group III) were also studied. A standard echocardiographic evaluation plus left (LV) and right ventricular global and regional transmural, endocardial, and epicardial longitudinal strain (LS) analysis, was performed. In group II, while LV ejection fraction, fractional shortening, and S' were not significantly reduced compared to controls, transmural global LS was significantly reduced to 19.3 ± 1.8 % in group II versus 20.9 ± 1.1 % in controls (p = 0.0003). Compared to controls, group II presented significant (p < 0.05) regional LS decrease in the basal infero-lateral, antero-lateral, latero-apical, infero-septal, and septo-apical segments. Moreover, LS of the latero-apical and the basal antero-lateral segments was significantly altered in the epicardium (p < 0.05) but not significantly in the endocardium. Global and regional LV LS analysis allows detection of AC in an early or non-diagnostic stage of the disease. Moreover, epicardial LS analysis allows the detection of abnormalities earlier than endocardial LS.
| Type: | Article |
|---|---|
| Title: | Epicardial myocardial strain abnormalities may identify the earliest stages of arrhythmogenic cardiomyopathy. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10554-015-0813-9 |
| Publisher version: | http://dx.doi.org/10.1007/s10554-015-0813-9 |
| Language: | English |
| Additional information: | Copyright The Author(s). All rights reserved. The final publication is available at Springer via http://dx.doi.org/10.1007/s10554-015-0813-9 |
| Keywords: | Arrhythmogenic cardiomyopathy, Cardiac imaging, Echocardiography, Myocardial strain, Speckle tracking |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1478252 |
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