John Baksi, A;
Davies, JE;
Hadjiloizou, N;
Baruah, R;
Unsworth, B;
Foale, RA;
Korolkova, O;
... Hughes, AD; + view all
(2016)
Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta.
International Journal of Cardiology
, 202
pp. 441-445.
10.1016/j.ijcard.2015.09.064.
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Abstract
Background: Wave reflection may be an important influence on blood pressure, but the extent to which reflections undergo attenuation during retrograde propagation has not been studied. We quantified retrograde transmission of a reflected wave created by occlusion of the left femoral artery in man. Methods: 20 subjects (age 31-83 years; 14 male) underwent invasive measurement of pressure and flow velocity with a sensor-tipped intra-arterial wire at multiple locations distal to the proximal aorta before, during and following occlusion of the left femoral artery by thigh cuff inflation. A numerical model of the circulation was also used to predict reflected wave transmission. Wave reflection was measured as the ratio of backward to forward wave energy (WRI) and the ratio of peak backward to forward pressure (Pb/Pf). Results: Cuff inflation caused a marked reflection which was largest at 5-10 cm from the cuff (change (Δ) in WRI = 0.50 (95% CI 0.38, 0.62); p < 0.001, ΔPb/Pf = 0.23 (0.18-0.29); p < 0.001). The magnitude of the cuff-induced reflection decreased progressively at more proximal locations and was barely discernible at sites > 40 cm from the cuff including in the proximal aorta. Numerical modelling gave similar predictions to those observed experimentally. Conclusions: Reflections due to femoral artery occlusion are markedly attenuated by the time they reach the proximal aorta. This is due to impedance mismatches of bifurcations traversed in the backward direction. This degree of attenuation is inconsistent with the idea of a large discrete reflected wave arising from the lower limb and propagating back into the aorta.
| Type: | Article |
|---|---|
| Title: | Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijcard.2015.09.064 |
| Publisher version: | http://dx.doi.org/10.1016/j.ijcard.2015.09.064 |
| Language: | English |
| Additional information: | Copyright © 2016 Elsevier B.V. This manuscript is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Wave reflection, Blood pressure, Hemodynamics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1477132 |
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