Paulus, W;
Rothwell, JC;
(2016)
Membrane resistance and shunting inhibition: where biophysics meets state-dependent human neurophysiology.
Journal of Physiology
, 594
(10)
pp. 2719-2728.
10.1113/JP271452.
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Abstract
Activation of neurons not only changes their membrane potential and firing rate but, as a secondary action reduces membrane resistance. This loss of resistance, or increase of conductance, may be of central importance in non-invasive magnetic or electric stimulation of the human brain since electrical fields cause larger changes in transmembrane voltage in resting neurones with low membrane conductances than in active neurones with high conductance. This may explain why both the immediate and after-effects of brain stimulation are smaller or even reversed during voluntary activity compared to rest. Membrane conductance is also increased during shunting inhibition, which accompanies the classic GABAa IPSP. This short-circuits nearby EPSPs and is suggested here to contribute to the magnitude and time course of short latency intracortical inhibition (SICI) and facilitation (ICF). This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Membrane resistance and shunting inhibition: where biophysics meets state-dependent human neurophysiology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/JP271452 |
| Publisher version: | http://dx.doi.org/10.1113/JP271452 |
| Language: | English |
| Additional information: | © 2016 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | TMS, rTMS, tDCS, tACS, tRNS, transcranial stimulation (TS), membrane resistance, state dependency |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1477060 |
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