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Development of mechano-responsive polymeric scaffolds using functionalized silica nano-fillers for the control of cellular functions

Griffin, M; Nayyer, L; Butler, PE; Palgrave, RG; Seifalian, AM; Kalaskar, DM; (2016) Development of mechano-responsive polymeric scaffolds using functionalized silica nano-fillers for the control of cellular functions. Nanomedicine: Nanotechnology, Biology and Medicine , 12 (6) pp. 1725-1733. 10.1016/j.nano.2016.02.011. Green open access

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Abstract

We demonstrate an efficient method to produce mechano-responsive polymeric scaffolds which can alter cellular functions using two different functionalized (OH and NH2) silica nano-fillers. Fumed silica-hydroxyl and fumed silica-amine nano-fillers were mixed with a biocompatible polymer (POSS-PCU) at various wt% to produce scaffolds. XPS and mechanical testing demonstrate that bulk mechanical properties are modified without changing the scaffold's surface chemistry. Mechanical testing showed significant change in bulk properties of POSS-PCU scaffolds with an addition of silica nanofillers as low as 1% (P<0.01). Scaffolds modified with NH2 silica showed significantly higher bulk mechanical properties compared to the one modified with the OH group. Enhanced cell adhesion, proliferation and collagen production over 14days were observed on scaffolds with higher bulk mechanical properties (NH2) compared to those with lower ones (unmodified and OH modified) (P<0.05) during in vitro analysis. This study provides an effective method of manufacturing mechano-responsive polymeric scaffolds, which can help to customize cellular responses for biomaterial applications.

Type: Article
Title: Development of mechano-responsive polymeric scaffolds using functionalized silica nano-fillers for the control of cellular functions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nano.2016.02.011
Publisher version: http://dx.doi.org/10.1016/j.nano.2016.02.011
Language: English
Additional information: Copyright © 2016 Published by Elsevier Inc. Open Access funded by Medical Research Council. Under a Creative Commons license http://creativecommons.org/licenses/by/4.0/
Keywords: Fumed silica, Hydroxyl and amine functionalization, Mechano-responsive scaffolds, Nanoparticles, Polyhedral oligomeric silsesquioxane
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1477006
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