Noyce, AJ;
Nalls, MA;
(2016)
Mendelian randomization: the key to understanding aspects of Parkinson's Disease causation?
Movement Disorders
, 31
(4)
pp. 478-483.
10.1002/mds.26492.
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Abstract
Parkinson's disease has multiple determinants and is associated with a wide range of exposures that appear to modify risk in traditional observational studies, including numerous lifestyle and environmental factors. Across other fields of medicine, Mendelian randomization has emerged as a powerful method to examine whether associations between exposures and disease outcomes are causal. Here we discuss the concept of Mendelian randomization, its potential relevance to Parkinson's disease, and suggest avenues through which the method could be employed to further understanding of the causal basis of Parkinson's disease. © 2015 International Parkinson and Movement Disorder Society.
| Type: | Article |
|---|---|
| Title: | Mendelian randomization: the key to understanding aspects of Parkinson's Disease causation? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mds.26492 |
| Publisher version: | http://dx.doi.org/10.1002/mds.26492 |
| Language: | English |
| Additional information: | © 2015 International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited |
| Keywords: | Mendelian randomization, Parkinson's disease, causation, observational study |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476615 |
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