Dong, L;
Wijesinghe, P;
Dantuono, J;
Sampson, D;
Munro, P;
Kennedy, B;
Oberai, A;
(2016)
Quantitative Compression Optical Coherence Elastography as an Inverse Elasticity Problem.
IEEE Journal of Selected Topics in Quantum Electronics
, 22
(3)
, Article 6802211. 10.1109/JSTQE.2015.2512597.
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Abstract
Quantitative elasticity imaging seeks to retrieve spatial maps of elastic moduli of tissue. Unlike strain, which is commonly imaged in compression elastography, elastic moduli are intrinsic properties of tissue, and therefore, this approach reconstructs images that are largely operator and system independent, enabling objective, longitudinal, and multisite diagnoses. Recently, novel quantitative elasticity imaging approaches to compression elastography have been developed. These methods use a calibration layer with known mechanical properties to sense the stress at the tissue surface, which combined with strain, is used to estimate the tissue’s elastic moduli by assuming homogeneity in the stress field. However, this assumption is violated in mechanically heterogeneous samples. We present a more general approach to quantitative elasticity imaging that overcomes this limitation through an efficient iterative solution of the inverse elasticity problem using adjoint elasticity equations. We present solutions for linear elastic, isotropic, and incompressible solids; however, this method can be employed for more complex mechanical models. We retrieve the spatial distribution of shear modulus for a tissue-simulating phantom and a tissue sample. This is the first time, to our knowledge, that the iterative solution of the inverse elasticity problem has been implemented on experimentally acquired compression optical coherence elastography data.
| Type: | Article |
|---|---|
| Title: | Quantitative Compression Optical Coherence Elastography as an Inverse Elasticity Problem |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/JSTQE.2015.2512597 |
| Publisher version: | http://dx.doi.org/10.1109/JSTQE.2015.2512597 |
| Language: | English |
| Additional information: | Copyright © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
| Keywords: | Compression optical coherence elastography, inverse elasticity problem, quantitative elasticity imaging, optical coherence tomography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476298 |
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