Lynch, M;
Duffell, LD;
Sandhu, M;
Srivatsan, S;
Deatsch, K;
Kessler, A;
Mitchell, GS;
... Rymer, WZ; + view all
(2016)
Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study.
Journal of Spinal Cord Medicine
, 40
(3)
pp. 295-303.
10.1080/10790268.2016.1142137.
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Abstract
INTRODUCTION: Acute intermittent hypoxia (AIH) enhances lower extremity motor function in humans with chronic incomplete spinal cord injury (SCI). AIH-induced spinal plasticity is inhibited by systemic inflammation in animal models. Since SCI is frequently associated with systemic inflammation in humans, we tested the hypothesis that pretreatment with the anti-inflammatory agent ibuprofen enhances the effects of AIH. METHODS: A randomized, double-blinded, placebo-controlled crossover design was used. Nine adults (mean age 51.1 ± 13.1 years) with chronic motor-incomplete SCI (7.7 ± 6.3 years post-injury) received a single dose of ibuprofen (800 mg) or placebo, 90 minutes prior to AIH. For AIH, 9% O2 for 90 seconds was interspersed with 21% O2 for 60 seconds. Maximal voluntary ankle plantar flexion isometric torque was assessed prior to, and at 0, 30, and 60 minutes post-AIH. Surface electromyography (EMG) of plantar flexor muscles was also recorded. RESULTS: Torque increased significantly after AIH at 30 (P = 0.007; by ∼20%) and 60 (P < 0.001; by ∼30%) minutes post-AIH versus baseline. Ibuprofen did not augment the effects of AIH. EMG activity did not increase significantly after AIH; however, there was a significant association between increases in torque and EMG in both gastrocnemius (R2 = 0.17, P < 0.005) and soleus (R2 = 0.17, P < 0.005) muscles. CONCLUSIONS: AIH systematically increased lower extremity torque in individuals with chronic incomplete SCI, but there was no significant effect of ibuprofen pretreatment. Our study re-confirms the ability of AIH to enhance leg strength in persons with chronic incomplete SCI.
| Type: | Article |
|---|---|
| Title: | Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/10790268.2016.1142137 |
| Publisher version: | https://doi.org/10.1080/10790268.2016.1142137 |
| Language: | English |
| Additional information: | Copyright © The Academy of Spinal Cord Injury Professionals, Inc. 2016. This is an Accepted Manuscript of an article published by Taylor & Francis in The Journal of Spinal Cord Medicine on 9 February 2016, available online: http://www.tandfonline.com/10.1080/10790268.2016.1142137. |
| Keywords: | Spinal cord injury, Hypoxia, Ibuprofen, Neuronal plasticity, Muscle strength dynamometer, Rehabilitation, Humans |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474660 |
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