Rutledge, MT; (2016) Auditory Cortex Responses in Freely Moving Mice. Doctoral thesis , UCL (University College London).

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Abstract

The pervasive nature of sound and the high temporal precision of the auditory system make the auditory sensory modality ideally suited to investigations into cortical temporal response properties and their behavioural correlates in freely moving animals. The mouse is an increasingly popular model system for such studies due to the availability of genetically modi fied strains and genetic tools for manipulating neural circuitry. In this thesis, I fi rst describe the development of a technique for reliable targeting of tetrode implants to the auditory cortex in mice of strains and ages which are not represented in standard mouse brain atlases. Based on analysis of data obtained from CBA/Ca mice using this technique, I then present a characterisation of auditory cortical responses recorded in awake freely moving mice, for forward suppression of responses to repeated tones. In particular, I show that for short-latency tone-evoked responses (occurring within 100 ms of tone onset), forward suppression in the awake animal can persist for several seconds. Suppression recovery periods were found to range from under 400ms to longer than 6400ms for a variety of di erent response pro les, at varying cortical laminar depths, with the dominant pro le of prolonged suppression lasting for several seconds for both excited and inhibited responses. The results indicate that prolonged temporal processes of suppression act upon both excitatory and inhibitory cortical circuits in the principal cortical layers (layers II to VI measured), and that prolonged forward suppression is a general physiological phenomenon which aff ects the cortical system in a generalised ubiquitous manner. This sets a precedent for further investigation of cortical function over multiple second time periods, and for advancing our understanding of human cortical disorders with the use of transgenic mouse models.

Type:	Thesis (Doctoral)
Title:	Auditory Cortex Responses in Freely Moving Mice
Event:	UCL (University College London)
Language:	English
UCL classification:	UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI:	https://discovery.ucl.ac.uk/id/eprint/1474435

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