Ansari, R;
Aherrahrou, R;
Aherrahrou, Z;
Erdmann, J;
Hüttmann, G;
Schweikard, A;
(2012)
Quantitative Analysis of Cardiomyocyte Dynamics with Optical Coherence Phase Microscopy.
In: Izatt, JA and Fujimoto, JG and Tuchin, VV, (eds.)
Proceedings of SPIE.
Society of Photo-Optical Instrumentation Engineers (SPIE): San Francisco, CA, USA.
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Abstract
Spectral domain optical coherence microscopy (OCM) is an interferometric imaging technique for three-dimensional reconstruction of biological samples. Phase sensitive implementation of OCM has generally been in common path interferometer configuration to obtain high phase stability, wh ich limits the numerical aperture of the imaging optics and the transverse resolution. Here, we describe the implemen tation of optical coherence phase microscope in asymmetric Linnik interferometer configuration, which provides phase stability of 0.5 milliradians along with high spatial resolution. Three-dimensional structural images and dynamic displacement images ob tained from spontaneously active cardiomyocytes demonstrate that the phase information could potentially be used for quantitative analysis of contraction dynamics, spatially resolved to sub-cellular structures.
| Type: | Proceedings paper |
|---|---|
| Title: | Quantitative Analysis of Cardiomyocyte Dynamics with Optical Coherence Phase Microscopy |
| Event: | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI |
| Location: | San Francisco, California, USA |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.911781 |
| Publisher version: | http://dx.doi.org/10.1117/12.911781 |
| Language: | English |
| Additional information: | © (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). |
| Keywords: | Optical coherence microscopy, Optical coherence ph ase microscopy, cardiomyocy tes, cellular physiology, cell dynamics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474290 |
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