Smith, ME;
Caspersen, MB;
Robinson, E;
Morais, M;
Maruani, A;
Nunes, JP;
Nicholls, K;
... Chudasama, V; + view all
(2015)
A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.
Organic and Biomolecular Chemistry
, 13
(29)
pp. 7946-7949.
10.1039/c5ob01205h.
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Abstract
Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.
| Type: | Article |
|---|---|
| Title: | A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5ob01205h |
| Publisher version: | http://dx.doi.org/10.1039/c5ob01205h |
| Language: | English |
| Additional information: | This journal is © The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474039 |
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