Maruani, A;
Savoie, H;
Bryden, F;
Caddick, S;
Boyle, R;
Chudasama, V;
(2015)
Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.
Chemical Communications
, 51
(83)
pp. 15304-15307.
10.1039/c5cc06985h.
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Abstract
Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free "click" assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.
| Type: | Article |
|---|---|
| Title: | Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5cc06985h |
| Publisher version: | http://dx.doi.org/10.1039/c5cc06985h |
| Language: | English |
| Additional information: | © Royal Society of Chemistry 2015 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1473853 |
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