Knipl, D;
Moghadas, SM;
(2016)
Comparative dynamics of monovalent and bivalent vaccination for immunologically unrelated pathogens.
Journal of Biological Systems
, 24
(1)
pp. 91-115.
10.1142/S0218339016500054.
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Abstract
Multivalent vaccines are designed to immunize against two or more pathogens in a single dose vaccination. A challenge for wide spread use of these vaccines is their lower protection efficacy compared to monovalent vaccines that immunize individuals against a single pathogen. We sought, for the first time, to evaluate the outcomes of bivalent and monovalent vaccines in terms of the reduction in the number of infections over time. For this evaluation, we developed epidemiological models governing the transmission dynamics of two immunologically unrelated pathogens, where immunity conferred by vaccination or natural infection of one pathogen does not provide any cross-protection against the other pathogen. We assumed that a monovalent vaccine provides full, but temporary, protection against a particular pathogen. While protecting against both pathogens requires two pathogen-specific monovalent vaccines, a single dose of the bivalent vaccine provides partial protection against both pathogens. We analyzed the two models to investigate the impact of vaccination. In addition to examining global behaviors and disease persistence of the models, we performed simulations to show the existence of a biologically feasible region for the bivalent vaccine to outperform monovalent vaccines for prevention of disease transmission using a lower number of vaccines.
Type: | Article |
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Title: | Comparative dynamics of monovalent and bivalent vaccination for immunologically unrelated pathogens |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1142/S0218339016500054 |
Publisher version: | http://dx.doi.org/10.1142/S0218339016500054 |
Language: | English |
Additional information: | Electronic version of an article published as Journal of Biological Systems, 24(1), 2016, pp. 91-115, 10.1142/S0218339016500054. Copyright © World Scientific Publishing Company: http://www.worldscientific.com/worldscinet/jbs. |
Keywords: | Bivalent Vaccination, Epidemic Modelling, Basic Reproduction Number, Stability Analysis, Persistence, Simulations |
UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1473760 |
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