Tata, M;
Ruhrberg, C;
Fantin, A;
(2015)
Vascularisation of the central nervous system.
Mechanisms of Development
, 138
(1)
pp. 26-36.
10.1016/j.mod.2015.07.001.
Preview |
Text
1-s2.0-S0925477315300022-main.pdf Download (778kB) | Preview |
Abstract
The developing central nervous system (CNS) is vascularised through the angiogenic invasion of blood vessels from a perineural vascular plexus, followed by continued sprouting and remodelling until a hierarchical vascular network is formed. Remarkably, vascularisation occurs without perturbing the intricate architecture of the neurogenic niches or the emerging neural networks. We discuss the mouse hindbrain, forebrain and retina as widely used models to study developmental angiogenesis in the mammalian CNS and provide an overview of key cellular and molecular mechanisms regulating the vascularisation of these organs.
| Type: | Article |
|---|---|
| Title: | Vascularisation of the central nervous system |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mod.2015.07.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.mod.2015.07.001 |
| Additional information: | © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | GPCR, Neuropilin, Semaphorin, VEGF, WNT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1473326 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
