Gonçalves, MR;
Johnson, SP;
Ramasawmy, R;
Pedley, RB;
Lythgoe, MF;
Walker-Samuel, S;
(2015)
Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis.
British Journal of Cancer
, 113
(8)
pp. 1168-1177.
10.1038/bjc.2015.270.
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Abstract
Solid tumours can undergo cycles of hypoxia, followed by reoxygenation, which can have significant implications for the success of anticancer therapies. A need therefore exists to develop methods to aid its detection and to further characterise its biological basis. We present here a novel method for decomposing systemic and tumour-specific contributions to fluctuations in tumour deoxyhaemoglobin concentration, based on magnetic resonance imaging measurements.
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