Gilbert-Kawai, E;
Sheperdigian, A;
Adams, T;
Mitchell, K;
Feelisch, M;
Murray, A;
Peters, M;
... Martin, D; + view all
(2015)
Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.
F1000 Research
, 4
, Article 90. 10.12688/f1000research.6297.1.
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Abstract
Oxygen availability falls with ascent to altitude and also as a consequence of critical illness. Because cellular sequelae and adaptive processes may be shared in both circumstances, high altitude exposure ('physiological hypoxia') assists in the exploration of the response to pathological hypoxia. We therefore studied the response of healthy participants to progressive hypobaric hypoxia at altitude. The primary objective of the study was to identify differences between high altitude inhabitants (Sherpas) and lowland comparators.
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