Screening neonatal jaundice based on the sclera color of the eye using digital photography

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Screening neonatal jaundice based on the sclera color of the eye using digital photography

Leung, TS; Kapur, K; Guilliam, A; Okell, J; Lim, B; MacDonald, LW; Meek, J; (2015) Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomedical Optics Express , 6 (11) pp. 4529-4538. 10.1364/BOE.6.004529. Green open access

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Abstract

A new screening technique for neonatal jaundice is proposed exploiting the yellow discoloration in the sclera. It involves taking digital photographs of newborn infants' eyes (n = 110) and processing the pixel colour values of the sclera to predict the total serum bilirubin (TSB) levels. This technique has linear and rank correlation coefficients of 0.75 and 0.72 (both p<0.01) with the measured TSB. The mean difference ( ± SD) is 0.00 ± 41.60 µmol/l. The receiver operating characteristic curve shows that this technique can identify subjects with TSB above 205 µmol/l with sensitivity of 1.00 and specificity of 0.50, showing its potential as a screening device.

Type:	Article
Title:	Screening neonatal jaundice based on the sclera color of the eye using digital photography
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1364/BOE.6.004529
Publisher version:	http://dx.doi.org/10.1364/BOE.6.004529
Language:	English
Additional information:	Copyright © 2015 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited.
Keywords:	(300.6550) Spectroscopy, visible, (330.1710) Color, measurement
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Civil, Environ and Geomatic Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI:	https://discovery.ucl.ac.uk/id/eprint/1472241