Das, S;
Lee, D;
Sillitoe, I;
Dawson, NL;
Lees, JG;
Orengo, CA;
(2015)
Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.
Bioinformatics
, 31
(21)
pp. 3460-3467.
10.1093/bioinformatics/btv398.
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Abstract
Computational approaches that can predict protein functions are essential to bridge the widening function annotation gap especially since <1.0% of all proteins in UniProtKB have been experimentally characterised. We present a domain-based method for protein function classification and prediction of functional sites that exploits functional subclassification of CATH superfamilies. The superfamilies are subclassified into functional families (FunFams) using a hierarchical clustering algorithm supervised by a new classification method, FunFHMMer.
| Type: | Article |
|---|---|
| Title: | Functional classification of CATH superfamilies: a domain-based approach for protein function annotation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/bioinformatics/btv398 |
| Publisher version: | http://dx.doi.org/10.1093/bioinformatics/btv398 |
| Language: | English |
| Additional information: | © The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1470163 |
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