Scadding, GK;
(2015)
Allergens, germs and asthma.
The Clinical Respiratory Journal
, 9
(2)
153 - 156.
10.1111/crj.12128.
Preview |
PDF
Scadding-2015-The_Clinical_Respiratory_Journal.pdf Available under License : See the attached licence file. Download (250kB) |
Abstract
Objective To explore asthma pathogenesis using data from upper and lower airways. Data Source English-language papers on human asthma and nasal polyp subjects from 1990 onwards. Study Selection High-quality studies in established journals. Results The recognition of its inflammatory nature led to a quantum leap in the understanding and treatment of asthma, with lives saved by inhaled corticosteroids. Further work at genetic, molecular, histological and clinical levels has shown that asthma is polymorphic and rarely involves isolated Th2 bronchial inflammation. Viral infections may act as an initiating event in children and adults, showing synergy with atopy. Chronic staphylococcal colonization of the mucosa may act as a promoter, as in atopic dermatitis. These two observations may be linked, with viruses providing an entry for bacteria into the mucosal epithelium. Conclusions Most asthma begins in the nose and involves allergy and infection: both viral and bacterial. The combination of atopy and infection suggests new possibilities for therapy.
Type: | Article |
---|---|
Title: | Allergens, germs and asthma |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1111/crj.12128 |
Publisher version: | http://dx.doi.org/10.1111/crj.12128 |
Language: | English |
Additional information: | © 2014 The Author. The Clinical Respiratory Journal published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. http://creativecommons.org/licenses/by-nc-nd/3.0/ |
UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
URI: | https://discovery.ucl.ac.uk/id/eprint/1469778 |
Archive Staff Only
View Item |