Marson, CM;
Yau, KC;
(2015)
Regioselective synthesis of substituted piperidine-2,4-diones and their derivatives via Dieckmann cyclisations.
Tetrahedron
, 71
(39)
pp. 7459-7469.
10.1016/j.tet.2015.06.052.
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Abstract
A flexible route to piperidine-2,4-diones variously substituted at the 6-, 5,6- and 2,6-positions, both with and without 1-substitution, is described; no N-protective group is required. A related regioselective Dieckmann cyclisation is also described that uses Davies' α-methylbenzylamine auxiliary and affords 6-substituted piperidine-2,4-diones enantioselectively.
| Type: | Article |
|---|---|
| Title: | Regioselective synthesis of substituted piperidine-2,4-diones and their derivatives via Dieckmann cyclisations |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tet.2015.06.052 |
| Publisher version: | http://dx.doi.org/10.1016/j.tet.2015.06.052 |
| Language: | English |
| Additional information: | © 2015 Elsevier B.V. After an initial embargo period, this manuscript is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Dieckmann cyclisation, piperidine-2,4-diones, regioselective synthesis, enantioselective synthesis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1469560 |
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