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Digital histology quantification of intra-hepatic fat in patients undergoing liver resection

Parkin, E; O'Reilly, DA; Plumb, AA; Manoharan, P; Rao, M; Coe, P; Frystyk, J; ... Renehan, AG; + view all (2015) Digital histology quantification of intra-hepatic fat in patients undergoing liver resection. European Journal of Surgical Oncology , 41 (8) pp. 1020-1027. 10.1016/j.ejso.2015.05.003. Green open access

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Abstract

High intra-hepatic fat (IHF) content is associated with insulin resistance, visceral adiposity, and increased morbidity and mortality following liver resection. However, in clinical practice, IHF is assessed indirectly by pre-operative imaging [for example, chemical-shift magnetic resonance (CS-MR)]. We used the opportunity in patients undergoing liver resection to quantify IHF by digital histology (D-IHF) and relate this to CT-derived anthropometrics, insulin-related serum biomarkers, and IHF estimated by CS-MR.

Type: Article
Title: Digital histology quantification of intra-hepatic fat in patients undergoing liver resection
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejso.2015.05.003
Publisher version: http://dx.doi.org/10.1016/j.ejso.2015.05.003
Language: English
Additional information: Copyright Elsevier 2015. This article is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Hepatic steatosis, Insulin resistance, Liver surgery, Obesity, Visceral adiposity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1468984
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