Marlow, N;
Morris, T;
Brocklehurst, P;
Carr, R;
Cowan, F;
Patel, N;
Petrou, S;
... Doré, CJ; + view all
(2015)
A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years.
Arch Dis Child Fetal & Neonatal Edition
, 100
(4)
F320-F326.
10.1136/archdischild-2014-307410.
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Abstract
We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). GM-CSF was associated with improved neonatal neutrophil counts, but no change in other neonatal or 2-year outcomes. As subtle benefits in outcome may not be ascertainable until school age we performed an outcome study at 5 years.
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