Banaji, M;
Mallet, A;
Elwell, CE;
Nicholls, P;
Cooper, CE;
(2008)
A model of brain circulation and metabolism: NIRS signal changes during physiological challenges.
PLoS Computational Biology
, 4
(11)
, Article e1000212. 10.1371/journal.pcbi.1000212.
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Abstract
We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2 levels, O2 levels, and functional activation. Significant model outputs are predictions about blood flow, metabolic rate, and quantities measurable noninvasively using near-infrared spectroscopy (NIRS), including cerebral blood volume and oxygenation and the redox state of the CuA centre in cytochrome c oxidase. These quantities are now frequently measured in clinical settings; however the relationship between the measurements and the underlying physiological events is in general complex. We anticipate that the model will play an important role in helping to understand the NIRS signals, in particular, the cytochrome signal, which has been hard to interpret. A range of model simulations are presented, and model outputs are compared to published data obtained from both in vivo and in vitro settings. The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli.
| Type: | Article |
|---|---|
| Title: | A model of brain circulation and metabolism: NIRS signal changes during physiological challenges |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pcbi.1000212 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pcbi.1000212 |
| Language: | English |
| Additional information: | © 2008 Banaji et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Human brain circulation, Mathematical model, Near infrared spectroscopy, Mitochondria, Cytochrome-c-oxidase |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/146803 |
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