Mlcochova, P;
Apolonia, L;
Kluge, SF;
Sridharan, A;
Kirchhoff, F;
Malim, MH;
Sauter, D;
(2015)
Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection.
Virology
, 482
pp. 72-78.
10.1016/j.virol.2015.03.015.
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Abstract
Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection.
| Type: | Article |
|---|---|
| Title: | Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.virol.2015.03.015 |
| Publisher version: | http://dx.doi.org/10.1016/j.virol.2015.03.015 |
| Additional information: | © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Accessory, Acute, Chronic, HIV, Nef, Vif, Vpu, Cell Line, Female, HIV Infections, HIV-1, Human Immunodeficiency Virus Proteins, Humans, Immune Evasion, Male, Viral Regulatory and Accessory Proteins, Virus Replication, nef Gene Products, Human Immunodeficiency Virus, vif Gene Products, Human Immunodeficiency Virus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1465369 |
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