A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

Morgan, RE; Chudasama, V; Moody, P; Smith, ME; Caddick, S; (2015) A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. Org Biomol Chem , 13 (14) 4165 - 4168. 10.1039/c5ob00130g. Green open access

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Abstract

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

Type:	Article
Title:	A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Location:	England
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1039/c5ob00130g
Publisher version:	http://dx.doi.org/10.1039/c5ob00130g
Language:	English
Additional information:	Copyright © Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification:	UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI:	https://discovery.ucl.ac.uk/id/eprint/1462917