Mao, Y;
Baum, B;
(2015)
Tug of war - The influence of opposing physical forces on epithelial cell morphology.
Developmental Biology
, 401
(1)
92 - 102.
10.1016/j.ydbio.2014.12.030.
Preview |
Text
Mao_MaoBaumManuscriptDec2014_template.pdf Download (199kB) | Preview |
Abstract
The shape of a single animal cell is determined both by its internal cytoskeleton and through physical interactions with its environment. In a tissue context, this extracellular environment is made up largely of other cells and the extracellular matrix. As a result, the shape of cells residing within an epithelium will be determined both by forces actively generated within the cells themselves and by their deformation in response to forces generated elsewhere in the tissue as they propagate through cell-cell junctions. Together these complex patterns of forces combine to drive epithelial tissue morphogenesis during both development and homeostasis. Here we review the role of both active and passive cell shape changes and mechanical feedback control in tissue morphogenesis in different systems.
| Type: | Article |
|---|---|
| Title: | Tug of war - The influence of opposing physical forces on epithelial cell morphology |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ydbio.2014.12.030 |
| Publisher version: | http://dx.doi.org/10.1016/j.ydbio.2014.12.030 |
| Language: | English |
| Additional information: | This article is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | Actin, Adhesion, Cell shape, Epithelial morphogenesis, Forces, Myosin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1462739 |
Archive Staff Only
 |
View Item |
