UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Learning-induced plasticity in medial prefrontal cortex predicts preference malleability.

Garvert, MM; Moutoussis, M; Kurth-Nelson, Z; Behrens, TE; Dolan, RJ; (2015) Learning-induced plasticity in medial prefrontal cortex predicts preference malleability. Neuron , 85 (2) 418 - 428. 10.1016/j.neuron.2014.12.033. Green open access

[thumbnail of 1-s2.0-S0896627314011428-main.pdf] PDF
1-s2.0-S0896627314011428-main.pdf

Download (1MB)

Abstract

Learning induces plasticity in neuronal networks. As neuronal populations contribute to multiple representations, we reasoned plasticity in one representation might influence others. We used human fMRI repetition suppression to show that plasticity induced by learning another individual's values impacts upon a value representation for oneself in medial prefrontal cortex (mPFC), a plasticity also evident behaviorally in a preference shift. We show this plasticity is driven by a striatal "prediction error," signaling the discrepancy between the other's choice and a subject's own preferences. Thus, our data highlight that mPFC encodes agent-independent representations of subjective value, such that prediction errors simultaneously update multiple agents' value representations. As the resulting change in representational similarity predicts interindividual differences in the malleability of subjective preferences, our findings shed mechanistic light on complex human processes such as the powerful influence of social interaction on beliefs and preferences.

Type: Article
Title: Learning-induced plasticity in medial prefrontal cortex predicts preference malleability.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2014.12.033
Publisher version: http://dx.doi.org/10.1016/j.neuron.2014.12.033
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Adult, Brain, Choice Behavior, Concept Formation, Female, Functional Neuroimaging, Humans, Interpersonal Relations, Learning, Magnetic Resonance Imaging, Male, Neostriatum, Neuronal Plasticity, Prefrontal Cortex, Social Identification, Social Perception, Social Values, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1461383
Downloads since deposit
138Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item