Rommer, PS;
Kamin, F;
Petzold, A;
Tumani, H;
Abu-Mugheisib, M;
Koehler, W;
Hoffmann, F;
... Zettl, UK; + view all
(2014)
Effects of Repeated Intrathecal Triamcinolone-Acetonide Application on Cerebrospinal Fluid Biomarkers of Axonal Damage and Glial Activity in Multiple Sclerosis Patients.
MOLECULAR DIAGNOSIS & THERAPY
, 18
(6)
631 - 637.
10.1007/s40291-014-0114-3.
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Abstract
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults. Over time, the disease progresses and, with accumulating disability, symptoms such as spasticity may occur. Although several treatment options are available, some patients may not respond to first-line therapeutics. However, some of these patients may benefit from intrathecally administered triamcinolone-acetonide (TCA), a derivative of glucocorticosteroids (GCS).GCSmay have neurotoxic effects, and cell apoptosis may occur. The aim of this study was to investigate the effects of TCA on biomarkers in the cerebrospinal fluid (CSF) suggestive of neurodegeneration.
| Type: | Article |
|---|---|
| Title: | Effects of Repeated Intrathecal Triamcinolone-Acetonide Application on Cerebrospinal Fluid Biomarkers of Axonal Damage and Glial Activity in Multiple Sclerosis Patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s40291-014-0114-3 |
| Publisher version: | http://dx.doi.org/10.1007/s40291-014-0114-3 |
| Additional information: | ©� The Author(s) 2014. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1459482 |
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