Kucuk, I;
Edirisinghe, M;
(2014)
Microfluidic preparation of polymer nanospheres.
Journal of Nanoparticle Research
, 16
(12)
p. 2626.
10.1007/s11051-014-2626-5.
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Abstract
In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is explained using high speed camera imaging. The polymer concentration (5-50 wt%) and flow rates of the feeds (50-300 µl min(-1)) were important parameters in controlling the nanosphere diameter. The diameter of the polymer nanospheres was found to be in the range of 80-920 nm with a polydispersity index of 11-19 %. The interior structure and surfaces of the nanospheres prepared were studied using advanced microscopy and showed the presence of fine pores and cracks on surface which can be used as drug entrapment locations.
| Type: | Article |
|---|---|
| Title: | Microfluidic preparation of polymer nanospheres |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11051-014-2626-5 |
| Publisher version: | http://dx.doi.org/10.1007/s11051-014-2626-5 |
| Language: | English |
| Additional information: | © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Microfluidics, Nanobiotechnology, Nanocarriers, Nanopheres, Perfluorohexane, Polymethylsilsesquioxane, Surface morphology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1459193 |
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