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Term and preterm labour are associated with distinct microbial community structures in placental membranes which are independent of mode of delivery.

Doyle, RM; Alber, DG; Jones, HE; Harris, K; Fitzgerald, F; Peebles, D; Klein, N; (2014) Term and preterm labour are associated with distinct microbial community structures in placental membranes which are independent of mode of delivery. Placenta , 35 (12) 1099 - 1101. 10.1016/j.placenta.2014.10.007. Green open access

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Abstract

Infection is considered a possible trigger for preterm labour, supported by evidence showing the presence of bacteria in the placenta and placental membranes from preterm births. In this study, 16S rDNA pyrosequencing was used to identify bacteria in placental membranes. Caesarean sections and vaginal deliveries at term were found to harbour common genera. Mycoplasma hominis, Aerococcus christensenii, Gardnerella vaginalis and Fusobacterium nucleatum were either only present in preterm membranes or in greater abundance than at term. These data support previous studies that used either targeted qPCR or broad-range 16S rDNA PCR and cloning but not a recent microbiome analysis of placental tissue using high-throughput sequencing.

Type: Article
Title: Term and preterm labour are associated with distinct microbial community structures in placental membranes which are independent of mode of delivery.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.placenta.2014.10.007
Publisher version: http://dx.doi.org/10.1016/j.placenta.2014.10.007
Language: English
Additional information: © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: 16S rDNA, High-throughput sequencing, Infection, Metagenetics, Placental membranes, Preterm labour
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1457783
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