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Epigenetic noise fuels cancer evolution

Swanton, C; Beck, SA; (2014) Epigenetic noise fuels cancer evolution. Cancer Cell , 26 (6) pp. 775-776. 10.1016/j.ccell.2014.11.003. Green open access

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Abstract

Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer’s evolutionary trajectory.

Type: Article
Title: Epigenetic noise fuels cancer evolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ccell.2014.11.003
Publisher version: http://dx.doi.org/10.1016/j.ccell.2014.11.003
Language: English
Additional information: Copyright © 2014. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/1456626
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