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The design and construction of an electrohydrodynamic cartesian robot for the preparation of tissue engineering constructs.

Hashimdeen, SH; Miodownik, M; Edirisinghe, MJ; (2014) The design and construction of an electrohydrodynamic cartesian robot for the preparation of tissue engineering constructs. PLoS One , 9 (11) , Article e112166 . 10.1371/journal.pone.0112166. Green open access

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Abstract

In this work we bring together replicating rapid prototyping technology with electrohydrodynamic phenomena to develop a device with the ability to build structures in three-dimensions while simultaneously affording the user a degree of designing versatility and ease that is not seen in conventional computer numerically controlled machines. An attempt at reproducing an actual human ear using polycaprolactone was pursued to validate the hardware. Five different polycaprolactone solution concentrations between 7-15 wt% were used and printing was performed at applied voltages that ranged from 1 to 6 kV and at flow rates from 5µl/min to 60µl/min. The corresponding geometrical and aesthetic features of the printed constructs were studied to determine the effectiveness of the device. The 15 wt% concentration at 60µl/min under an applied electric field of 6 kV was identified as the best operating parameters to work with.

Type: Article
Title: The design and construction of an electrohydrodynamic cartesian robot for the preparation of tissue engineering constructs.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0112166
Publisher version: http://dx.doi.org/10.1371/journal.pone.0112166
Language: English
Additional information: © 2014 Hashimdeen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1456559
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