Yu Wai Man, C;
Khaw, PT;
(2015)
Developing novel anti-fibrotic therapeutics to modulate post-surgical wound healing in Glaucoma: big potential for small molecules.
Expert Review of Ophthalmology
, 10
(1)
pp. 65-76.
10.1586/17469899.2015.983475.
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Abstract
Ocular fibrosis leads to significant visual impairment and blindness in millions of people worldwide, and is one of the largest areas of unmet need in clinical ophthalmology. The antimetabolites, mitomycin C and 5-fluorouracil, are the current gold standards used primarily to prevent fibrosis after glaucoma surgery, but have potentially blinding complications like tissue damage, breakdown, and infection. This review thus focuses on the development of new classes of small molecule therapeutics to prevent post-surgical fibrosis in the eye, especially in the context of glaucoma filtration surgery. We discuss recent advances and innovations in ophthalmic wound healing research, including antibodies, RNA interference, gene therapy, nanoparticles, liposomes, dendrimers, proteoglycans, and small molecule inhibitors. We also review the challenges involved in terms of drug delivery, duration of action, and potential toxicity of new anti-fibrotic agents in the eye.
| Type: | Article |
|---|---|
| Title: | Developing novel anti-fibrotic therapeutics to modulate post-surgical wound healing in Glaucoma: big potential for small molecules |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1586/17469899.2015.983475 |
| Publisher version: | http://dx.doi.org/10.1586/17469899.2015.983475 |
| Language: | English |
| Additional information: | © 2014 The Authors. This is an open-access article distributed under the terms of the CC-BY-NC-ND 3.0 License which permits users to download and share the article for non-commercial purposes, so long as the article is reproduced in the whole without changes, and provided the original source is credited. |
| Keywords: | antibody, RNA interference, gene therapy, nanoparticle, inhibitor, glaucoma filtration surgery, ocular fibrosis, wound healing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1456310 |
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